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Rudolph's Pediatrics, 22e

Colin D. Rudolph, Abraham M. Rudolph, George E. Lister, Lewis R. First, Anne A. Gershon

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Section 1. Fundamentals of Pediatrics

Section 2. Health Promotion and Disease Prevention

Section 3. Nutrition

Section 4. Abuse, Neglect, Violence

Section 5. Newborn

Section 6. Principles of Adolescent Care

Section 7. Developmental and Behavioral Pediatrics

Section 8. The Acutely Ill Infant and Child

Section 9. The Chronically Ill Infant and Child

Section 10. Transplantation

Section 11. Inherited Disorders of Metabolism

Section 12. Clinical Genetics and Dysmorphology

Section 13. Immunologic Disorders

Section 14. Allergic Disorders

Section 15. Rheumatology

Section 16. The Musculoskeletal System

Section 17. Infectious Diseases

Section 18. Disorders of the Skin

Section 19. Disorders of the Ear, Nose, and Throat

Section 20. Disorders of the Oral Cavity

Section 21. Disorders of the Gastrointestinal System

Section 22. Disorders of the Liver and Biliary Tree

Section 23. Disorders of the Blood

Section 24. Neoplastic Disorders

Section 25. Disorders of the Kidney and Urinary Tract

Section 26. Disorders of the Cardiovascular System

Section 27. Disorders of the Respiratory System

Section 28. Disorders of the Endocrine System

Section 29. Disorders of the Nervous System

Section 30. Disorders of the Eyes

Chapter 1	Role of the Pediatrician
Chapter 2	Decision Making: Use of Evidence-Based Medicine
Chapter 3	Communication
Chapter 4	Interviewing Techniques
Chapter 5	Systems of Practice and Office Management
Chapter 6	Core Competencies
Chapter 7	Patient and Family-Centered Care
Chapter 8	Disaster Preparedness
Chapter 9	Law, Ethics, and Clinical Judgment

Part 1. Health Maintenance Issues
Chapter 10	Well-Child Care
Chapter 11	Child Development
Chapter 12	Screening
Chapter 13	Oral Health Supervision
Chapter 14	Complementary and Alternative Medicine (CAM)
Chapter 15	Culture and Pediatric Practice
Chapter 16	Gay and Lesbian Parents
Chapter 17	Environmental Pediatrics
Chapter 18	Travel Medicine
Part 2. Managing Family Transition
Chapter 19	Family Function and Birth of a Child
Chapter 20	Foster Care and Adoption
Chapter 21	Family Discord and Divorce
Chapter 22	Supporting the Grieving Child and Family

Chapter 23	Normal Nutritional Requirements
Chapter 24	Breast-Feeding
Chapter 25	Infant Formula and Complementary Foods
Chapter 26	Postdischarge Nutritional Management of the Premature Infant
Chapter 27	Nutritional Issues: Toddler to Adolescent
Chapter 28	Assessment of Nutritional Adequacy
Chapter 29	Malnutrition and Refeeding
Chapter 30	Poor Weight Gain
Chapter 31	Approach to the Infant and Child with Feeding Difficulty
Chapter 32	The Overweight or Obese Child
Chapter 33	Specialized Nutrition Support
Chapter 34	Nutritional Access Devices

Chapter 35	Child Maltreatment: Neglect to Abuse
Chapter 36	Family and Community Violence
Chapter 37	Child Abuse Prevention: What Pediatricians Can Do

Part 1. Care of the Newborn
Chapter 38	Historical Perspectives
Chapter 39	Care of the Fetus
Chapter 40	Fetal Disorders
Chapter 41	Neonatal Mortality and Morbidity
Chapter 42	Delivery Room Resuscitation
Chapter 43	Transitional Changes in the Newborn
Chapter 44	Examination of the Newborn Infant
Chapter 45	Postnatal Care and Observation
Part 2. Infants at Risk
Chapter 46	Multiple Births
Chapter 47	The Small-for-Gestational-Age Infant
Chapter 48	Infant of a Diabetic Mother
Part 3. Specific Neonatal Conditions
Chapter 49	Approach to the Cyanotic Infant
Chapter 50	Abnormalities of the Lungs
Chapter 51	Metabolic Abnormalities
Chapter 52	Brain Abnormalities and Injuries
Chapter 53	Hematologic Abnormalities and Jaundice
Part 4. Disorders Specifically Related to Preterm Birth
Chapter 54	Respiratory Distress Syndrome
Chapter 55	Patent Ductus Arteriosus and Ductus Venosus
Chapter 56	Hemodynamics
Chapter 57	Necrotizing Enterocolitis
Chapter 58	Intraventricular Hemorrhage
Chapter 59	Bronchopulmonary Dysplasia
Chapter 60	Emergencies
Chapter 61	Special Intensive Care
Chapter 62	Outcomes of Preterm and Term Infants

Part 1. Growth and Development
Chapter 63	Somatic Growth and Development
Chapter 64	Reproductive Growth and Development in the Female Adolescent
Chapter 65	Reproductive Growth and Development in the Male Adolescent
Chapter 66	Psychological Development
Chapter 67	The Adolescent Visit
Part 2. Health Problems of Adolescents
Chapter 68	Mortality
Chapter 69	Morbidity
Chapter 70	Sexual Behavior
Chapter 71	Substance Use and Abuse
Part 3. Mental Health Disorders in the Adolescent
Chapter 72	Depression, Anxiety, and Other Disorders
Chapter 73	Disorders of Eating
Part 4. Reproductive Health Problems
Chapter 74	Breast Masses
Chapter 75	Scrotal Masses
Chapter 76	Menstrual Problems
Chapter 77	Intrauterine and Ectopic Pregnancy
Chapter 78	Contraception

Part 1. General Concepts
Chapter 79	Introduction to Developmental and Behavioral Pediatrics
Chapter 80	Fundamental Concepts of Child Development
Chapter 81	Brain Development and Behavior
Chapter 82	Standardized Developmental Screening and Assessment Instruments
Part 2. Developmental Variation to Disorder
Chapter 83	Crying in Infants
Chapter 84	Hyperactivity and Inattention
Chapter 85	Learning Problems
Chapter 86	Language Delay
Chapter 87	Difficult Behavior
Chapter 88	Anxiety
Chapter 89	Repetitive Behaviors
Chapter 90	Gender Identity and Sexual Behavior
Chapter 91	Developmental Delay
Part 3. Major Psychopathologic Disorders
Chapter 92	Autistic Spectrum Disorders
Chapter 93	Affective Disorders and Suicide
Chapter 94	Pediatric Condition Falsification
Chapter 95	Childhood Schizophrenia
Part 4. Psychosocial Context of Development and Behavior
Chapter 96	Families in the 21st Century: An Introduction to Families
Chapter 97	Nonparental Childcare
Chapter 98	Vulnerable Child Syndrome
Chapter 99	Adaptation to Illness
Chapter 100	Poverty, Homelessness, and Social Disorganization
Chapter 101	Resiliency in Children and Adolescents

Part 1. Assessment of the Acutely Ill Infant and Child
Chapter 102	Respiratory Distress and Failure
Chapter 103	Decreased Perfusion and Circulatory Shock
Chapter 104	Acute Neurological Dysfunction
Chapter 105	The Febrile Child
Part 2. Stabilization and Management of the Acutely Ill Infant and Child
Chapter 106	Monitoring of Vital Function
Chapter 107	Vascular Access
Chapter 108	Cardiopulmonary Resuscitation
Chapter 109	Life Support Systems
Chapter 110	Stabilization and Transport
Chapter 111	Management of Cerebral Edema and Elevated Intracranial Pressure
Chapter 112	Perioperative Care
Chapter 113	Pain Management and Sedation
Chapter 114	Acute Metabolic Dysfunction
Part 3. Injuries and Untoward Events
Chapter 115	Acute Inflammation
Chapter 116	Trauma, Burns, and Bites
Chapter 117	Submersion Injury
Chapter 118	Foreign-Body Aspiration
Chapter 119	Apparent Life-Threatening Events and SIDS
Chapter 120	Toxic Ingestions and Exposures
Chapter 121	Heat Stress
Chapter 122	Poisonous Bites and Stings

Part 1. The Changing Outlook of Chronic Illness in Childhood
Chapter 123	Psychological and Behavioral Responses
Chapter 124	The Technology-Dependent Child
Part 2. Death and Dying in Childhood
Chapter 125	Caring for Children Dying from Chronic Disease
Chapter 126	Hospice and Palliative Care
Chapter 127	Law, Ethics, and Caring Near the End of Life

Chapter 128	Pediatric Transplantation
Chapter 129	Kidney Transplantation
Chapter 130	Liver Transplantation
Chapter 131	Intestinal and Multivisceral Transplant
Chapter 132	Heart Transplant
Chapter 133	Hematopoietic Cell Transplantation

Part 1. Inborn Errors of Metabolism
Chapter 134	Principles of Inborn Errors of Metabolism
Part 2. Disorders of Amino Acid (AA) and Organic Acid (OA) Metabolism
Chapter 135	Hyperphenylal-Aninemias
Chapter 136	Disorders of Tyrosine Metabolism
Chapter 137	Disorders of Branched Chain Amino and Organic Acid Metabolism
Chapter 138	Disorders of Sulfur-Containing Amino Acid Metabolism
Chapter 139	Disorders of Glycine, Serine, and Proline Metabolism
Chapter 140	Disorders of Metabolism of Lysine, Hydroxylysine, and Related Compounds
Chapter 141	Disorders of Metabolism of Neurotransmitter Amino Acids
Chapter 142	Disorders of Creatine and Ornithine Metabolism
Chapter 143	Disorders of Amino Acid Transport Across Cell Membranes
Chapter 144	Other Disorders of Amino Acid Metabolism
Chapter 145	Urea Cycle and Related Disorders
Part 3. Inborn Errors of Water Soluble Vitamins
Chapter 146	Introduction
Chapter 147	Vitamin B₁₂ and Folic Acid
Chapter 148	Biotin Responsive Disorders
Chapter 149	Vitamin B₆ and Vitamin B₁Responsive Disorders
Part 4. Disorders of Fatty Acid Oxidation, Ketogenesis, and Ketolysis
Chapter 150	Disorders of Fatty Acid Oxidation
Chapter 151	Disorders of Ketogenesis
Chapter 152	Disorders of Ketolysis
Chapter 153	Disorders of Leukotriene Synthesis and Fatty Aldehyde Dehydrogenase
Part 5. Carbohydrate Metabolism
	Introduction to Carbohydrate Metabolism
Chapter 154	Disorders of Glycogen Metabolism
Chapter 155	Disorders of Galactose and Fructose Metabolism and Gluconeogenesis
Chapter 156	Disorders of Pentose Phosphate Pathway
Chapter 157	Disorders of Glucose Transporters
Part 6. Disorders of Oxidative Phosphorylation and Pyruvate Oxidation
Chapter 158	Respiratory Chain Disorders
Chapter 159	Disorders of Energy Metabolism
Part 7. Organelle Related Disorders
Chapter 160	Mucopolysaccharidosis, Glycoproteinosis, and Mucolipidosis
Chapter 161	Sphingolipidoses
Chapter 162	Peroxisomal Disorders
Chapter 163	Congenital Disorders of Glycosylation
Part 8. Disorders of Lipid and Bile Acid Metabolism
Chapter 164	Disorders of Cholesterol Synthesis
Chapter 165	Disorders of Bile Acid Synthesis
Chapter 166	Disorders of Lipid and Lipoprotein Metabolism
Part 9. Disorders of Nucleic Acids, Heme Metabolism, and Metals Transport
Chapter 167	Disorders of Heme Biosynthesis: The Porphyrias
Chapter 168	Disorders of Purine and Pyrimidine Metabolism
Chapter 169	Disorders of Metal Metabolism

Part 1. The Genetic Approach to Disorders of Children
Chapter 170	Key Principles in Human Genetics
Chapter 171	Multifactorial Inheritance
Chapter 172	Principles of Care
Part 2. Chromosomal Disorders
Chapter 173	Human Cytogenetics
Chapter 174	Chromosome Disorders
Part 3. Birth Defects, Malformations, and Syndroms
Chapter 175	Birth Defects, Malformations, and Syndromes
Chapter 176	Syndromes of Multiple Congenital Anomalies/Dysplasias
Chapter 177	Craniofacial Disorders
Chapter 178	Approach to the Child with Birth Defects
Chapter 179	Genetic Skeletal Disorders
Chapter 180	Congenital Contractures
Chapter 181	Connective Tissue Dysplasias
Chapter 182	Neurocutaneous Disorders
Chapter 183	Environmental Causes of Birth Defects
Chapter 184	Disorders of Accelerated Aging
Chapter 185	Genetic Evaluation of Developmental Delay/Mental Retardation

Chapter 186	Overview of the Immune System
Chapter 187	Undue Susceptibility to Infection
Chapter 188	Primary Immunodeficiencies
Chapter 189	Complement Disorders

Chapter 190	Allergic Disease and Atopy
Chapter 191	Clinical Aspects of Allergic Diseases
Chapter 192	Allergic Rhinitis and Conjunctivitis
Chapter 193	Anaphylaxis, Urticaria, and Angioedema
Chapter 194	Food Allergy
Chapter 195	Insect Allergy
Chapter 196	Latex Allergy
Chapter 197	Adverse Reactions to Drugs

Part 1. General Principles in Rheumatology
Chapter 198	Pathogenesis of Inflammatory and Autoimmune Disorders
Chapter 199	History and Physical Examination in Rheumatology
Chapter 200	Diagnostic Testing in Rheumatology
Part 2. Specific Rheumatologic Disorders
Chapter 201	Juvenile Idiopathic Arthritis
Chapter 202	Spondyloarthropathies
Chapter 203	Vasculitides
Chapter 204	Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease
Chapter 205	Juvenile Dermatomyositis
Chapter 206	Scleroderma
Part 3. Systemic Syndromes in Rheumatology
Chapter 207	Musculoskeletal Pain Syndromes
Chapter 208	Chronic Fatigue Syndrome
Chapter 209	Autoinflammatory Disorders

Part 1. Principles of Infectious Disease
Chapter 222	Bacterial Pathogenesis
Chapter 223	Bacteremia, Sepsis, and Septic Shock
Chapter 224	Viral Pathogenesis
Chapter 225	Infection Control
Chapter 226	Diagnostic Approaches for Infectious Diseases
Chapter 227	Acute Fever Without a Focus
Chapter 228	Fever of Unknown Origin
Chapter 229	Fever and Infection in the Immunocompromised Patient
Chapter 230	Therapy for Perinatal and Neonatal Infections
Part 2. Infections of Organ Systems
Chapter 231	Bacterial Infections of the Central Nervous System
Chapter 232	Viral Infections of the Central Nervous System
Chapter 233	Sexually Transmitted Infections
Chapter 234	Bone, Joint, Soft Tissue Infections
Chapter 235	Cardiac Infections
Chapter 236	Gastrointestinal Infections
Chapter 237	Infections of the Liver
Chapter 238	Urinary Tract Infections
Chapter 239	Catheter-Associated Infections
Part 3. Infections of the Respiratory System
Chapter 240	Community-Acquired and Bacterial Pneumonia in Children
Chapter 241	Viral Respiratory Infections Including Influenza
Chapter 242	Fungal Respiratory Infections
Chapter 243	Infections of the Ear
Part 4. Treatment and Prevention of Infectious Diseases
Chapter 244	Immunizations
Chapter 245	Antiviral Therapy
Chapter 246	Antibacterial Therapy
Chapter 247	Antifungal Therapy
Part 5. Bacterial Infections
Chapter 248	Actinomycosis
Chapter 249	Anaerobic Bacterial Infections
Chapter 250	Clostridial Infections
Chapter 251	*Anthrax (Bacillus anthracis)*
Chapter 252	Arcanobacterium
Chapter 253	*Bacillus Cereus*
Chapter 254	Brucellosis
Chapter 255	**Burkholderia and Pseudomonas**
Chapter 256	*Campylobacter*

Part 1. Principles of Blood Disorders
Chapter 428	Approach to Suspected Hematologic Disorders
Chapter 429	Hematopoeisis
Part 2. Disorders of Red Blood Cells and Anemia
Chapter 430	Anemia
Chapter 431	Iron Deficiency
Chapter 432	Anemia Due to Diminished Red Blood Cell Production
Chapter 433	Hemolytic Anemia
Chapter 434	Hemoglobinopathies
Part 3. Disorders of Coagulation and Platelets
Chapter 435	Normal and Abnormal Hemostasis
Chapter 436	Inherited Bleeding Disorders
Chapter 437	Acquired Coagulation Disorders
Chapter 438	Diagnosis and Management of Thrombosis
Chapter 439	Disorders of Platelets
Part 4. Disorders of the Spleen and Lymph Nodes
Chapter 440	The Spleen and Lymph Nodes
Part 5. Disorders of White Blood Cells
Chapter 441	Disorders of Granulocytes
Part 6. Transfusion Medicine
Chapter 442	Transfusion Medicine

Part 1. Principles of Oncology
Chapter 443	Cancer Genetics and Biology
Chapter 444	Epidemiology of Childhood Cancer
Chapter 445	Chemotherapy and Radiation Therapy
Chapter 446	Clinical Trials in Pediatric Oncology
Chapter 447	Neonatal Oncology
Chapter 448	Cancer Survivorship and Recommendations for Follow-Up
Part 2. Hematologic Malignancies
Chapter 449	Acute Lymphoblastic Leukemia
Chapter 450	Myeloid Malignancies
Chapter 451	Non-Hodgkin Lymphoma
Chapter 452	Hodgkin Lymphoma
Part 3. Solid Tumors
Chapter 453	Osteosarcoma
Chapter 454	Ewing Sarcoma and Primitive Neuroectodermal Tumor
Chapter 455	Rhabdomyosarcoma
Chapter 456	Renal Tumors
Chapter 457	Neuroblastoma
Chapter 458	Malignant Liver Tumors
Chapter 459	Germ Cell Tumors
Chapter 460	Brain Tumors and Spinal Tumors
Chapter 461	Retinoblastoma
Chapter 462	Vascular Neoplasms
Part 4. Mononuclear Phagocytic System Disorders
Chapter 463	Histiocytic Disorders

Chapter 210	Growth and Development
Chapter 211	The Limping Child
Chapter 212	Torsional and Angular Deformities
Chapter 213	Disorders of the Foot
Chapter 214	Disorders of the Knee
Chapter 215	Developmental Dysplasia of the Hip
Chapter 216	Disorders of the Neck and Spine
Chapter 217	Disorders of the Upper Extremity
Chapter 218	Injuries
Chapter 219	Tumors
Chapter 220	Neuromuscular Disorders
Chapter 221	Common Orthopedic Misses

Chapter 356	Functional Overview
Chapter 357	Neonatal Dermatology
Chapter 358	Disorders of the Epidermis
Chapter 359	Disorders of the Dermis and Subcutaneous Tissue
Chapter 360	Genetic Disorders of the Skin
Chapter 361	Melanocytic Lesions and Disorders of Pigmentation
Chapter 362	Immunologic Diseases
Chapter 363	Neoplastic and Proliferative Disorders
Chapter 364	Vascular Tumors and Malformations
Chapter 365	Acne and Other Disorders of the Pilosebaceous Unit
Chapter 366	Disorders of Nails
Chapter 367	Skin Infections and Exanthems
Chapter 368	Infestations

Chapter 369	The Ear
Chapter 370	Nose and Sinus
Chapter 371	The Pharynx and Upper Airway
Chapter 372	The Head, Face, and Neck
Chapter 373	Head and Neck Masses

Chapter 374	Dental Caries
Chapter 375	Dental Emergency Care
Chapter 376	Dental Occlusion and Its Management
Chapter 377	Periodontal and Gingival Health and Diseases
Chapter 378	Oral Pathology
Chapter 379	Temporomandibular Joint Disorders
Chapter 380	Behavioral Treatment Options in Pediatric Dentistry

Part 1. Presenting Signs and Symptoms
Chapter 381	Normal Structure and Function of the Gastrointestinal Tract
Chapter 382	Approach to the Child with Acute, Chronic, or Cyclic Vomiting
Chapter 383	Acute Abdominal Pain
Chapter 384	Chronic Abdominal Pain
Chapter 385	Diarrhea
Chapter 386	Constipation and Fecal Incontinence
Chapter 387	Upper and Lower Gastrointestinal Bleeding
Chapter 388	Abdominal Masses
Chapter 389	Gastrointestinal Obstruction
Chapter 390	Protein-Losing Enteropathy
Chapter 391	Gastrointestinal Disorders Associated with Immunodeficiency
Part 2. Esophageal Disorders
Chapter 392	Anatomic Disorders of the Esophagus
Chapter 393	Disorders of Esophageal Motility
Chapter 394	Gastroesophageal Reflux and Other Causes of Esophageal Inflammation
Chapter 395	Other Esophageal Disorders
Part 3. Congenital and Anatomic Disorders of the Stomach and Intestine
Chapter 396	Abdominal Wall Defects
Chapter 397	Malrotation and Volvulus
Chapter 398	Infantile Hypertrophic Pyloric Stenosis
Chapter 399	Congenital Atresias, Stenosis, and Webs
Chapter 400	Microgastria and Gastric Perforation
Chapter 401	Duplications and Cysts
Chapter 402	Omphalo-Mesenteric Duct Remnants
Chapter 403	Meconium Diseases of Infancy and Distal Intestinal Obstruction Syndrome
Chapter 404	Intussusception
Chapter 405	Inguinal and Other Hernias
Chapter 406	Superior Mesenteric Artery Syndrome
Chapter 407	Motor Disorders of the Stomach, Small Bowel, and Colon
Part 4. Disorders of Digestion and Absorption
Chapter 408	Disorders of Digestion and Absorption
Part 5. Disorders of the Stomach and Intestine
Chapter 409	Inflammatory Disorders of the Stomach
Chapter 410	Inflammatory Bowel Disease
Chapter 411	Allergic and Eosinophilic Gastroenteropathies
Chapter 412	Vascular, Systemic, and Other Disorders Affecting the Gastrointestinal Tract
Chapter 413	Acute Appendicitis, Typhlitis, and Chronic Appendicitis
Chapter 414	Polyps and Tumors of the Gastrointestinal Tract
Chapter 415	Congenital Anomalies of the Anorectum
Chapter 416	Other Anorectal Disorders
Part 6. The Exocrine Pancreas
Chapter 417	Disorders of the Exocrine Pancreas

Chapter 418	Structure and Function of the Liver
Chapter 419	Evaluation of the Infant and Child with Liver Disease
Chapter 420	Autoimmune Disorders of the Liver
Chapter 421	Metabolic and Genetic Disorders of the Liver
Chapter 422	Drug, Toxin, and TPN Liver Disease
Chapter 423	The Liver in Systemic Disease
Chapter 424	Acute Liver Failure
Chapter 425	End-Stage Liver Disease
Chapter 426	Other Disorders of the Liver
Chapter 427	The Biliary Tract

Part 1. Principles of Nephrology
Chapter 464	Renal Morphogenesis
Chapter 465	Development of Renal Function
Chapter 466	Fluid, Electrolyte, and Acid-Base Disorders
Chapter 467	Diagnostic Approach to Renal Disease
Part 2. Abnormalities of the Kidney and Urinary Tract
Chapter 468	Kidney or Urinary Tract Disorders
Chapter 469	Renal Malformations
Chapter 470	Cystic Diseases of the Kidney
Chapter 471	Acute Renal Failure
Chapter 472	Glomerular Diseases
Chapter 473	Hereditary Glomerulopathies
Chapter 474	Renal Tubular Disorders
Chapter 475	Urinary Tract Stone Diseases
Chapter 476	Urologic Abnormalities of the Genitourinary Tract
Part 3. Chronic Kidney Disease
Chapter 477	Chronic Kidney Disease
Chapter 478	Chronic Dialysis
Chapter 479	Systemic Hypertension

Part 1. Principles of Cardiology
Chapter 480	Development of the Cardiovascular System
Chapter 481	Genetics of Heart Disease
Part 2. Approach to the Patient with Cardiovascular Disease
Chapter 482	Fetal Cardiology
Chapter 483	Neonate and Infant with Cardiovascular Disease
Chapter 484	Congenital Heart Disease
Chapter 485	Arrhythmias
Chapter 486	Child and Adolescent with Cardiovascular Disease
Part 3. Acquired Cardiovascular Disease
Chapter 487	Cardiac Tumors
Chapter 488	Kawasaki Disease
Chapter 489	Diseases of Myocardium
Chapter 490	Infective Endocarditis
Chapter 491	Pericardial Diseases
Chapter 492	Pulmonary Hypertension
Part 4. Diagnostic Tools in Heart Disease
Chapter 493	Electrocardiography
Chapter 494	Radiologic Imaging
Chapter 495	Echocardiography
Chapter 496	Cardiac Catherization
Part 5. Management of Patients with Cardiovascular Disease
Chapter 497	Heart Failure
Chapter 498	The Patient with Single Ventricle
Chapter 499	Interventional Cardiology
Chapter 500	Health Care Management for the Child with Cardiovascular Disease
Chapter 501	Sports Screening for Cardiovascular Risk

Part 1. Principles of Pulmonology
Chapter 502	Lung Growth in Infancy and Childhood
Chapter 503	Physiologic Basis of Pulmonary Function
Chapter 504	Global Burden of Respiratory Infections and Mucosal Immunology of the Respiratory Tract
Chapter 505	Clinical Presentation of Respiratory Illness
Chapter 506	Tools for Diagnosis and Management of Respiratory Disease
Part 2. Disorders of the Respiratory System
Chapter 507	Congenital Disorders of the Lower Airways and Mediastinum
Chapter 508	Disorders of Respiratory Control and Sleep-Disordered Breathing
Chapter 509	Sleep Disorders
Chapter 510	Disorders Causing Airway Obstruction
Chapter 511	Aspiration Syndromes
Chapter 512	Asthma
Chapter 513	Bronchopulmonary Dysplasia
Chapter 514	Cystic Fibrosis
Chapter 515	Interstitial Lung Disease
Chapter 516	Alpha-1 Antitrypsin Deficiency Lung Disease
Chapter 517	Pulmonary Vasculitis Syndromes
Chapter 518	Pulmonary Alveolar Proteinosis
Chapter 519	Chest Wall and Respiratory Muscle Disorders

Chapter 520	Mechanisms of Hormone Action
Chapter 521	Disorders of the Anterior Pituitary Gland
Chapter 522	Growth and Growth Impairment
Chapter 523	Endocrine Abnormalities Causing Growth Impairment
Chapter 524	Tall Stature
Chapter 525	Primary Disturbances in Water Homeostasis
Chapter 526	The Thyroid
Chapter 527	Hypothyroidism in the Infant
Chapter 528	Acquired Hypothyroidism
Chapter 529	Hyperthyroidism
Chapter 530	Other Disorders of the Thyroid
Chapter 531	The Adrenal Cortex
Chapter 532	Evaluation of Adrenal Function
Chapter 533	Genetic Lesions in Steroidogenesis
Chapter 534	Adrenal Insufficiency
Chapter 535	Adrenal Excess
Chapter 536	Glucocorticoid Therapy and Withdrawal
Chapter 537	Endocrine Neoplasia Syndromes
Chapter 538	Normal Human Sex Differentiation
Chapter 539	Disorders of Sexual Development (DSD)
Chapter 540	Normal Pubertal Development
Chapter 541	Abnormal Pubertal Development
Chapter 542	Calcium, Phosphorus, and Magnesium Metabolism
Chapter 543	Disorders of Bone Formation
Chapter 544	Diabetes Mellitus
Chapter 545	Endocrine Causes of Hypoglycemia

Part 1. Principles of Neurology
Chapter 546	Introduction to Neurology
Chapter 547	Clinical Approach to Neurologic Disease
Part 2. Abnormal Development of the Nervous System
Chapter 548	Cranial Developmental Abnormalities
Chapter 549	Disturbances of the Neural Tube and Spine Closure
Chapter 550	Macrocephaly and Microcephaly
Part 3. Acute Deterioration of Neurologic Function
Chapter 551	Trauma to the Nervous System
Chapter 552	Stroke and Cerebrovascular Disease
Chapter 553	Hydrocephalus and Pseudotumor Cerebri
Chapter 554	Cerebral Palsy and Static Encephalopathies
Chapter 555	Infections of the Central Nervous System
Chapter 556	Immune- and Inflammatory-Mediated Central Nervous System Syndromes
Part 4. Epilepsy
Chapter 557	Epidemiology of Epilepsy, Seizure Classification, Epilepsy Syndromes
Chapter 558	Etiologies of Epilepsies
Chapter 559	Febrile Seizures
Chapter 560	Evaluation of New Onset Seizures
Chapter 561	Status Epilepticus
Chapter 562	Epilepsy Treatment: Antiepileptic Drug Therapy
Chapter 563	Epilepsy Treatment: Ketogenic Diet and Neurostimulation
Chapter 564	Epilepsy Treatment: Surgery
Part 5. Paroxysmal Disorders
Chapter 565	Migraine and Headache Disorders
Chapter 566	Movement Disorders, Tics, and Tourette Syndrome
Chapter 567	Other Paroxysmal Disorders
Part 6. Disorders of Strength, Tone, and Sensation
Chapter 568	General Evaluation of Strength, Tone, and Sensation
Chapter 569	The Hypotonic Infant
Chapter 570	Peripheral Nerve Disorders and Anterior Horn Cell Diseases
Chapter 571	Diseases of the Neuromuscular Junction
Chapter 572	Myopathies
Part 7. Developmental Delay and Regression
Chapter 573	Neurologic Aspects of Disorders of Metal Metabolism
Chapter 574	Lysosomal Storage Disorders
Chapter 575	*Rett Syndrome (MECP2-Related Disorders)*
Chapter 576	Leukoencephalopathies
Chapter 577	Neurotransmitter Disorders
Chapter 578	Phakomatoses

Part 1. General Principles
Chapter 579	Anatomy and Physiology of the Eye and Ocular System
Chapter 580	Office Evaluation of the Eyes
Chapter 581	Special Tests of the Eyes
Chapter 582	International Pediatric Ophthalmology
Part 2. Disorders of the Eye
Chapter 583	Eye Emergencies and Trauma
Chapter 584	Visual Impairment in Childhood
Chapter 585	Amblyopia
Chapter 586	Strabismus
Chapter 587	The Eye in Child Abuse
Chapter 588	Red Eye
Chapter 589	Lid and Lacrimal System Disorders
Chapter 590	Anterior Segment Disorders
Chapter 591	Retinopathy of Prematurity
Chapter 592	Genetic Eye Diseases
Chapter 593	Optic Nerve Disorders